Compartment-Selective XTC MRI at 1.5T and 3T
نویسندگان
چکیده
Introduction: Hyperpolarized xenon-129 (HXe-129) spectroscopy has revealed at least two dissolved-phase compartments in the lung: xenon bound to hemoglobin at 200-225 ppm (depending on the species and oxygenation level) and xenon dissolved in lung tissue and blood plasma at approximately 197 ppm [1,2]. In this work we demonstrate the feasibility of obtaining gas-phase depolarization maps in humans using Xenon polarization Transfer Contrast (XTC) MRI [3,4] by selectively inverting the magnetization in one of the two compartments [5]. By choosing sufficiently long delay times, these depolarization maps can be converted to blood-to-airspace-volume or tissue-to-airspace-volume maps. Preliminary results at 1.5T and 3T are presented.
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